11th International Symposium on Polymer Therapeutics

Final Program

(Download Link)

 

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Monday 23rd MAYRegistration and Poster Mounting

 

                                                       7.45-9.00      Registration & Poster Mounting

9.00    Welcome and Opening Remarks

           Dr Enrique Alborch. Director. Centro de Investigación Príncipe Felipe (Valencia, Spain)

           Dr María J. Vicent. Centro de Investigación Príncipe Felipe (Valencia, Spain)

Introductory Remarks

Chairmen: M. J. Vicent

9.15 IL1. Ruth Duncan (Cardiff, UK) Polymer Therapeutics: Current Status and Quality by Design (QbD)

Plenary

Chairmen: M.J. Vicent

9.45-10.30 PL1. Kazunori Kataoka (University of Tokyo, Japan) • Polymeric Micelles: From a Rational Design to Clinical Development

 

10.30-11.00    Coffee/Tea • Posters

New Synthetic Approaches and analytical Tools I

Chairmen: M. Malkoch and C. Alexander

11.00 IL2. Andreas Heise (Royal College of Surgeons, Ireland) Well-defined polypeptides for therapeutic delivery

11.30 IL3. Dalia Pinkert (TEVA Pharmaceuticals, Israel) Characterization of Copaxone® By 2D RP-MALLS (Multi Angle Laser Light Scattering)

12.00-12.15 O1. pH-switchable Supramolecular Polymers. Hendrik Frisch, Patrick Ahlers, Daniel Spitzer, Pol Besenius  (Johannes Gutenberg-Universität Mainz, Germany)

12.15-12.30 O2. Polypept(o)ides: A Material Designed to Reduce Synthetic Complexity, while Providing Functionality to Achieve Therapeutic Activity M. Barz, A. Birke, R. Holm, D. Huesmann, K. Klinker,O. Schäfer, B. Weber (Johannes Gutenberg-University of Mainz, Germany)

 

12.30-13.00Short Poster Introductions (3 min each)

Chairmen: C. Decker and M. Barz

  • P1.PeptoStars – A new versatile polypept(o)idic architecture as ideal platform for nano drug delivery systems in anti-cancer therapy. Regina Holm, Matthias Barz ( Johannes Gutenberg-Universität Mainz, Germany)
  • P2.Use of SANS and SAXS to Study the Inner Structure in Solution of 3-arm Star Shaped Polyglutamates Amaya Niño-Pariente, A. Duro-Castaño, A. Paul, MJ. Vicent (CIPF, Spain)
  • P3.Controlled cleavable cross-linkers for nanohydrogel particles. Jana Marie Stahlhofen, Nadine Leber, Rudolf Zentel, Siegfried R. Waldvogel (Johannes Gutenberg University, Germany).
  • P4. One-pot synthesis and in line drug-loaded vesicles assembly: from monomers to drug-loaded vesicles in few hoursFrancesca Mastrotto, Alastair Breen, Giovanna Sicilia, Georgina E. Marsh, Christine Grainger-Boultby, Sudax Murdan, Cameron Alexander,Giuseppe Mantovani (University of Nottingham, UK)
  • P5.Novel protecting and activating group for reactive cysteines and its application in biodegradable nanopeptogels. Olga Schäfer , David Huesmann, K. Klinker, Matthias Barz (Johannes Gutenberg University Mainz, Germany)
  • P6.Self-assembly of supramolecular nanotubes into tubisomes: Mimicking a Virus Capsule. Johannes C. Brendel, Joaquin Sanchis-Martinez, Sébastien Perrier (University of Warwick, UK and Monash Inst. Pharmaceutical Sciences, Australia)
  • P7.Cyclic peptide-polymer conjugates: self-assembling vectors for drug delivery. Sophie C. Larnaudie,Johannes C. Brendel,Sébastien Perrier(University of Warwick, UK)
  • P8.Control over Charge and Charge Density in Micelles from ABC Triblock Terpolymers: Effects on Interaction with Cells. F. H. Schacher (Friedrich-Schiller-University Jena, Germany)
  • P9. Peptomicelles: core cross-linked polymeric micelles based on reactive polypept(o)ides. K. Klinker, D. Huesmann, L. Braun, O. Schäfer, L. Capelôa, B. Weber, M. Barz (Johannes Gutenberg-University of Mainz, Germany
  • P10. Janus-type tubisomes as drug delivery non-viral vectors. Joaquin Sanchis-Martinez, Johannes Brendel, Katrina A. Jolliffe, Sébastien Perrier (Monash University. Australia)

13.00-14.15    Lunch and Poster Viewing

Plenary

Chairmen: S. Brocchini

14.15-15.00 PL2. Mark Frigerio (Polytherics, UK) • The importance of linking chemistry: From Antibody-Drug Conjugates to Polymer Conjugates

 

Products in Clinical Development/Clinical Use I 

Chairmen: C. Alexander and P. Dhal 

15.00 IL4. David Owen (StarPharma, Australia) DEPTM Docetaxel: preclinical evaluation and early clinical translation 

15.30 IL5. Cristianne Rijcken (Cristal Therapeutics, Netherlands) CriPec® Nanomedicines: Principles, preparation, preclinical evaluation and early clinical translation 

16.00 IL6. Derek Maclean(Relypsa, Inc. USA) Application of Relypsa Polymer Technology Platform: The Development of Patiromer for Lowering Serum Potassium Concentration in Patients with Hyperkalemia. 

16.30-16.45 O3. Polyoxazoline-modified lysine dendrimers to improve the therapeutic index of SN-38, the active metabolite of irinotecan. Richard M. England, Jennifer I. Hare, Paul D. Kemmitt, Mike J. Waring, Simon Barry, Cameron Alexander,Marianne Ashford ­(AstraZeneca, UK) 

16.45-17.15   Coffee • Posters 

17.15-17.30    Short Poster Introductions (3 min each) 

Chairmen: J. Sanchis and R. Luxenhofer    

  • P11. Antitumor and metastatic efficacy of a polymer-based paclitaxel conjugate for prostate cancer therapy. Yolanda Fernández,Julie Movellan, Laia Foradada, Vanessa Giménez, Natalia García-Aranda, Sandra Mancilla, Ana Armiñán, Simó Schwartz Jr, María J. Vicent, Ibane Abasolo. (CIBBIM-Nanomedicine, VHIR, Spain)
  • P12. N-term Modification of Interferon α2a by Hyaluronic Acid for the Local Treatment of Ovarian Cancer. Antonella Grigoletto, Anna Mero, Isabella Montagner, Antonio Rosato, Gianfranco Pasut. (University of Padova, Italy)
  • P13. pH-sensitive polymersomes targeted with CendR peptides for treatment of peritoneal carcinomatosis. Lorena Simón Gracia, Hedi Hunt, Pablo Scodeller, Jens Gaitzsch, Erkki Ruoslahti, Giuseppe Battaglia, Tambet Teesalu (University of Tartu, Estonia)
  • P14. A comparative study of folate receptor-targeted doxorubicin delivery systems: dosing regimens and therapeutic index. Anna Scomparin, Stefano Salmaso, Anat Eldar-Boock, Dikla Ben-Shushan, Shiran Ferber, GaliaTiram, Hilary Shmeeda, Natalie Landa-Rouben, Jonathan Leor, Paolo Caliceti, Alberto Gabizon, Ronit Satchi-Fainaro(Tel Aviv Univ., Israel)
  • P15. Laminine derived peptide-polymer drug conjugate for targeting CD44 overexpressing cancer cells. Michal Zaiden, Ayelet David (Ben-Gurion University of the Negev, Israel) 

New Synthetic Approaches and analytical Tools II 

Chairmen: V.J. Nebot and T. Etrych 

17.30 IL7. Atsushi Maruyama (Tokyo Institute of Technology, Japan) • Design of polymer materials to activate functional DNA and peptides 

18.00 IL8. Sergey K. Filippov (Inst. Macromolecular Chemistry, Czech Republic) Use of SAXS/SANS to study the kinetics hydrolytic degradation of polymer micelles 

18.30-18.45 O4. Practical Linking Technologies of Payloads to Synthetic Polymer Carriers or to Biomolecules Thomas Bruckdorfer (Iris Biotech Gmb, Germany) 

18.45-19.00 O5. Controlled polymer architectures for probing cell uptake mechanism Sébastien Perrier (University Warwick, UK) 

19.00-19.15   Short Poster Introductions (3 min each) 

Chairmen: M. Malkoch and I. Conejos-Sánchez 

  • P16. Near Infrared Activatable Poly-L-Glutamic Acid-Phthalocyanine Conjugate for Effective Anticancer Photodynamic Therapy. Hoay Yan Cheah, Kia Hui Ng, Lik Voon Kiew, Hong Boon Lee, Elena Gallon, Julie Movellan, Fabienne Dumoulin,Serkan Alpugan, Maria J. Vicent,Lip Yong Chung(CIPF, Spain)
  • P17.Improved Pharmacokinetic Profile of PLITIDEPSIN Using aVb3-targeted Polyurethane-Polyurea Nanoparticles.Yolanda Fernández, Pau Rocas, Natalia García-Aranda, Laia Foradada, Pilar Calvo, Pablo Avilés, María José Guillén, Simó Schwartz Jr., Josep Rocas, Fernando Albericio, Ibane Abasolo (CIBBIM-Nanomedicine, VHIR, Spain)
  • P18. Doubly-Amphiphilic Poly(2-oxazoline)s in High-capacity Drug Formulations: Structure-Property relationships and tumor inhibition in Aggressive orthotopic Tumor models Robert Luxenhofer, Zhijian He, Anita Schulz, Xiaomeng Wan, Rainer Jordan, Alexander V. Kabanov (Julius-Maximilians-Universität Würzburg, Germany)
  • P19. Metabolomic study of polymer-Doxorubicin conjugates in breast cancer models. A. Armiñán, M. Palomino, C. Deladriere, A. Pineda-Lucena, M.J. Vicent (CIPF, Spain)
  • P20. MAbs/fc binding proteins complexes as new targeted drug delivery systems. Katia Maso, Giulia Dall’Anese, Anna Mero, Isabella Montagner, Antonio Rosato, Gianfranco Pasut (University of Padova, Italy) 

Combination Therapeutics 

Chairmen: C. Li 

19.15 IL9. Lawrence D. Mayer (Celator Pharmaceuticals, Canada) • Phase 3 Trial for VYXEOS™ (CPX-351) in High-Risk AML Demonstrates Statistically Significant Improvement in Overall Survival, Validating CombiPlex Technology and Opening Numerous Opportunities for Nanoparticle Delivered Novel Anti-cancer Combinations. 

19.45 -20.10  Short Poster Introductions (3 min) 

Chairmen: A. Armiñán and F. Greco 

  • P21. pH-labile PGA-Doxorubicin based Combination conjugates with enhanced antitumor activity in Breast Cancer models.J.J. Arroyo, D. Charbonnier, A. Armiñán, M.J. Vicent (CIPF, Spain)
  • P22. Pancreatic Cancer Therapy using Polyion Complex Micelles Loaded with Cyclopamine and Paclitaxel. Jun Zhao, Junjie Li, Wanqin Wang, Qian Huang, Xiaoxia Wen, Chun Li (MD Anderson Cancer Center, Houston, USA)
  • P23. A Curcumin-Polyacetal Combined with Ependymal Progenitor/Stem Cells Synergistically Enhance Functional Recovery after Spinal Cord Injury. Raquel Requejo-Aguilar, Ana Alastrue-Agudo, Marta Cases-Villar, Eric López-Moncholi, Richard England, María J. Vicent, Victoria Moreno-Manzano (CIPF, Spain)
  • P24. In vivo study of a dendritic polymer bearing a combination of doxorubicin and paclitaxel at a synergistic ratio. Laura Vossen, Hemda Cohen, Harald R. Krüger, Ela Markovsky, Stefanie Wedepohl, Ronit Satchi-Fainaro, Marcelo Calderón, (Freie Universität Berlin, Germany)
  • P25. Rational design of polyglutamic acid delivering an optimized combination of drugs targeting melanoma brain metastases. Evgeni Pisarevsky, Yana Epshtein, Dikla Ben-Shushan, Anat Eldar-Boock, Ronit Satchi-Fainaro (Tel Aviv University, Israel)
  • P26. Redox-responsive polymeric nanoparticles for the potential combined therapy of lung cancer. Claudia Conte, Francesca Mastrotto, Vincenzo Taresco, Snow Stolnik-trenkic, Cameron Alexander (Univ. Nottingham, UK)
  • P27. Development of polymer-based combination therapeutics for the treatment of castration-resistant prostate cancer (CRPC) Sonia Vicente-Ruiz, Ana Armiñan, Irene Casanova, Elena Gallon, Julie Movellan, María García, David Charbonnier, Jose A. López, María J. Vicent (CIPF, Spain)
  • P28. Polymer Therapeutics and Stem Cell Therapies as a Combinatorial Approach for the Treatment of Chronic Spinal Cord Injuries. Vicent J. Nebot, Ana Armiñán, Ana Alastrue-Agudo, Raquel-Aguilar, Victoria Moreno, María J. Vicent (CIPF, Spain) 

20.10-20.40    Poster Viewing 

20.45                                                  Welcome Dinner • At Oceanografic. Restaurante Submarino. 


TUESDAY 24TH MAY 

Challenging Biological Barriers 

Chairmen: R. Duncan

Plenary 

9.00 PL3. Justin Hanes (Johns Hopkins University, Baltimore, USA)Mucus Penetrating Nanoparticles: From Concept to Success in the Clinic 

Other Diseases-Oral Administrations 

Chairmen: S. Muro and P. Caliceti 

9.45 IL10. Ana P. Pêgo (i3S, Porto, Portugal) Modified-Chitosan/siRNA Polyplexes Downregulate Cellular CDX2 Expression and Cross the Gastric Mucus Barriers 

10.15 IL11. Jean-Chistophe Leroux (ETH Zurich, Switzerland)Macromolecular drugs in Celiac disease 

10.45-11.00 Short Poster Introductions (3 min each) 

Chairmen: P. Seib and P. Caliceti 

  • P29. Chitosan-alginate microcapsules provide gastric protection and intestinal release and targeting of anti-ICAM nanocarriers in vivo. Rasa Ghaffarian, Edgar Pérez-Herrero, Hyuntaek O, Srinivasa R. Raghavan, Silvia Muro (University of Maryland, USA)
  • P30. Novel mucoadhesive polymeric micelle-based nanogels by non-covalent crosslinking. Alejandro Sosnik, Chen Moshe, Yuval Davizon, Inbar Schlachet, Maya Menaker Raskin (Technion-Israel Institute of Technology, Israel)
  • P31. Synthesis of a new soft matter material, behaving as drug penetration enhancer, in nails.Barbara S Gregori, Clara SB Gomes,Pedro T Gomes, Jose R Ascenso, Paulo M Gordo, Lidia Gonçalves, João M Bordado, Helena Ribeiro (iMed.UL, Portugal)
  • P32. Development of Biodegradable Hyperbranched Core-Multishell (CMS) Nanocarriers for Efficient Topical Drug Delivery. Fang Du, Stefan Hönzke, Falko Neumann, Juliane Keilitz, Nan Ma, Sarah Hedtrich, Rainer Haag (Freie Universität Berlin, Germany)
  • P33. Thermoresponsive nanogels as a novel class of cutaneous penetration enhancers M. Giulbudagian, F. Rancan, A. Klossek, K. Yamamoto, J. Jurisch, E. Rühl, U. Blume-Peytavi, A. Vogt, M. Calderón(Freie Universität Berlin, Germany) 

11.00-11.45    Coffee/Tea • Posters 

Conference Picture (All Delegates and Grantees) 

Imaging and Theranostics 

Chairmen: G.F. Pasut and R. Satchi-Fainaro 

11.45 IL12. Marcelo Calderon (Freie Universität Berlin, Germany) Use of dendritic polymer imaging systems for the evaluation of conjugate uptake and cleavage 

12.15 IL13. Alex Adronov (McMaster University, Ontario, Canada) Synthesis, radiolabeling and in vivo imaging of PEGylated high generation Polyester Dendrimers 

12.45-13.00 O6. Bifunctional linear dendritic self-assembled theranostics targeting breast cancer - Oliver C. J. Andrén, Yuning Zhang, Andreas M. Nyström, Michael Malkoch (KTH Royal Inst. Technol., Sweden), 

13.00-13.15 O7. Photodynamic therapy and imaging based on tumor-targeted nanoprobe, pHPMA-conjugated zinc protoporphyrin, and its augmentation - Jun Fang, Hideaki Nakamura, Vladmimir Subr, Karel Ulbrich, Hiroshi Maeda (Sojo University, Japan) 

13.15-13.40   Short Poster Introductions (3 min each) 

Chairmen: E. Gallon and S. Salmaso 

  • P34. Water-soluble NIR-absorbing rylene chromophores for visualisation of cellular organelles and trafficking studies of nanocarriers. Stefka Kaloyanova, Yulian Zagraniarskyand Kalina Peneva (Max Planck Inst. Polymer Research, Germany)
  • P35. Controlled delivery of therapeutics using nanotechnology –multiplicity of nanofection concept.Rosario Mª Sánchez-Martín, Juan D. Unciti-Broceta, Victoria Cano-Cortés, Patricia Altea Manzano, Juan J. Díaz-Mochón. (Univ. Granada, Spain)
  • P36. Semi-interpenetrated polymeric near-infrared absorbing nanogels for efficient photothermal therapy of cancer. Loryn E. Fechner, Mrityunjoy Kar, Maria Molina, Stefanie Wedepohl, Marcelo Calderón (Freie Universität Berlin, Germany)
  • P37. Synthesis and characterisation of sulfated perylene bisimides as reactive fluorescence labels and their conjugates with biomolecules. Katharina Huth, Christian Kühne, Katharina Achazi, Timm Heek, Jens Dernedde, Rainer Haag (Freie Universität Berlin, Germany)
  • P38. Polymeric sensors as imaging tools for local pH in biofilm for early detection of microbial induced corrosion. Harald R. Krüger, Katrin Hoffmann, Karin Schwibbert, Janin Sameith, Jörg Toepel, Ute Resch-Geng (Federal Institute for Materials Research and Testing, Germany)
  • P39. Protease-degradable polymeric nanomedicine bearing paclitaxel and a turn-on fluorescent probe for cancer theranostics Yana Epshtein, Hemda Baabur-Cohen, Rachel Blau, Evgeni Pisarevsky, Orit Redy-Keisar, Einat Kisin-Finfer, Doron Shabat, Ronit Satchi-Fainaro (Tel Aviv University, Israel)
  • P40. Evaluation of drug release from theranostic macromolecular prodrugs by different triggers. Gregor Nagel, Harald R. Krüger, Stefanie Wedepohl, Marcelo Calderón (Freie Universität Berlin, Germany)
  • P41 Polymeric photothermal nanoparticles with potential application in spatiotemporal control of transgene expression by NIR. María Rosa Aguilar, Angela L. Del Duca, Raquel Palao-Suay, Sergio Martín-Saldaña, Francisco M. Martín-Saavedra, Nuria Vilaboa, Julio San Román. (ICTP-CSIC, Spain) 

13.40-15.00    Lunch and Poster Viewing 

Challenges for Development of Innovative and Follow-on Polymer Therapeutics 

Chairmen: R. Gaspar and S. Svenson 

15.00 IL14. Meenu Wadhwa (National Inst. Biological Standards and Controls, UK Medicines and Health Regulatory Agency)The importance of standards for complex follow-on products: a PEG-G-CSF standard 

15.30 IL15. Robert Luxenhofer (Julius-Maximilians-University, Würzburg, Germany) Reproducibility in Polymer Science and Polymer Therapeutics: Consequences for Research, Translation, and Society 

16.00-16.15 O8. Analytical Tools Promoting Quality by Design (QbD). D. Grela, S. Safi. (Iesmat-Malvern, Spain) 

16.15-16.30  Short Poster Introductions (3 min each) 

Chairmen: S. Muro and S. Salmaso 

  • P42. Poly HPMA-based hybrid structures for targeted pDNA delivery. Simone Beck, Jennifer Schultze, Hans-Joachim Räder, Rudolf Zentel (Johannes Gutenberg University Mainz, Germany)
  • P43. Polypept(o)ides as novel non-viral Vectors for Gene Therapy P. Heller, B. Weber, J. Zhou, D. Hobernik, M. Bros, M. Barz (Johannes Gutenberg University Mainz, Germany)
  • P44. HPMA copolymer-octaarginine conjugates for siRNA delivery and gene silencing Moran Golan, Ayelet David (Ben-Gurion University of the Negev, Israel)
  • P45. Design, synthesis and characterization of novel polymeric nanocarriers for oligonucleotides Adva Krivitsky, Dina Polyak, Anna Scomparin, Shay Eliyahu, Asaf Ori, Sharon Avkin Nachum, Vadim Krivitsky, Ronit Satchi-Fainaro(Tel Aviv University, Israel)
  • P46. Biodegradable dendritic structures: synthesis and biofunctionality assessment as nucleic acid vectors. Victoria Leiro, João Garcia, Pedro Moreno, Eduardo Fernandez-Megia, Ana Paula Pêgo(INEB, Univ. Porto, Portugal) 

Antiviral and Antibiotic Therapeutics 

Chairmen: J. San Roman 

16.30 IL16. Alexander N. Zelikin (Aarhus University, Denmark) Macromolecular (pro)drugs as antiviral agents 

17.00-17.15 O9. In vivo sub-acute toxicity and pharmacokinetics of repeated dosing of dextrin-colistin conjugates. E. L. Ferguson, P.F. Chan, C. Singley, D.W. Thomas. (Cardiff University, UK) 

17.15-17.45  Coffee • Posters 

Antiviral and Antibiotic Therapeutics 

17.45 -18.00  Short Poster Introductions (3 min each) 

Chairmen: E. Ferguson and A. Zelikin 

  • P47. Targeting macrophages for the treatment of intracellular pathogens infections. Loris Rizzello, Phil Elks, Dimitrios Evangelopulos, Julio Ortiz Canseco, Steven A. Renshaw, Timothy McHugh, Giuseppe Battaglia (UCL, UK)
  • P48. Broad-spectrum antiviral agents – Drug-carrying polyanions towards a universal treatment against viruses. Camilla Frich Riber, Alexander N. Zelikin(Aarhus University, Denmark)
  • P49. Anti-HIV latency treatment with macromolecular prodrugs of panobinostat. Kaja Zuwala, Anton A.A. Smith, Martin Tolstrup, Alexander N. Zelikin (Aarhus University, Denmark)
  • P50. Nanoemulsion-based chitosan nanocapsules as efficient delivery system for bedaquiline antibiotic. L. De Matteis, A. Lucía, S. García, I. Serrano, D.Pérez, J.A. Ainsa, J.M. de la Fuente (INA-CSIC, Spain)
  • P51. PHPMA copolymers for oncolytic virotherapy. Nora Francini, Daniel Cochrane, Sebastian Spain, Giuseppe Mantovani, Kerry Fisher, Leonard Seymour, Cameron Alexander (University of Nottingham, UK) 

The Immune System as Target 

Chairmen: D. Thomas 

18.00-18.15 O10. Designing polymeric materials for targeted modulation of the immune system Bruno G. De Geest(Ghent University, Belgium) 

18.15 -18.30 Selected Short Talk (3 min) 

Chairmen: D. Thomas and M. Barz 

  • P52. Biomimetic Vaccine nanogels for lymph node focused immune activation Lutz Nuhn, Nane Vanparijs,Ans De Beuckelaer,Lien Lybaert, Glenn Verstraete, Kim Deswarte, Stephan Lienenklaus, Nikunj M. Shukla, Alex C. D. Sayler, Bart N. Lambrecht, Johann Grooten, Sunil A. David, Stefaan De Koker, Bruno G. De Geest. (Ghent University, Belgium)
  • P53. HPMA-based amphiphilic blockcopolymer micelles for size controlled core cross linking for tumour immunotherapy Stefan Kramer, Kyung Oh Kim, Rudolf Zentel (Johannes Gutenberg University Mainz, Germany)
  • P54. Polymeric Brushes for Application in Tumor Immune TherapyM. Schinnerer, C. Kappel, S. Decker, J. Schultze, M. Diken, M. Bros, K. Fischer, M. Barz, S. Grabbe, M. Schmidt(Johannes Gutenberg University Mainz, Germany)
  • P55. PAMAM dendrimer interactions on the lipid interface Marleen Wilde, Rebecca. J. Green, Francesca Greco (University of Reading, UK)
  • P56. Surface modified polymersomes as drug carriers. Redouane Krini, Sandra Schürer, Martin Scherer, Benjamin Weber, Robert Ose, Helmut Jonuleit, Rudolf Zentel (Johannes Gutenberg-University of Mainz, Germany) 

Diseases of an Aging Population and Regenerative Strategies 

Chairmen: J. San Román 

18.30-18.45 O11. Redox Injectable Gels for Local Inflammation Treatments Yukio Nagasaki (University of Tsukuba, Japan) 

18.45-19.00 O12. Approaching CNS disorders by overcoming the BBB with the aid of targeted self-assembled nanocarriers Aroa Duro-Castaño, V.J. Nebot, A. Niño-Pariente, M.J Vicent (CIPF, Spain) 

19.00 -19.30 Short Poster Introductions (3 min each) 

Chairmen: A. Duro-Castaño and E. Ferguson 

  • P57. Polymeric nanomicelles of a-lipoic acid for ocular treatment of diabetes-induced corneal damage. Fernando Alvarez-Rivera, David Fernández Villanueva, Angel Concheiro, Carmen Alvarez-Lorenzo (Univ. Santiago de Compostela, Spain)
  • P58. Fibroblast growth factor 2 dimer with superagonist in vitro activity improves granulation tissue formation during wound healing Caitlin G. Decker, Yu Wang, Samantha J. Paluck, Lu Shen, Joseph A. Loo, Alex J. Levine, Lloyd S. Miller, Heather D. Maynard (Univ. California Los Angeles, USA)
  • P59. siRNA-mediated gene silencing through polymer-based polyplexes for progressive MS treatment.I. Conejos-Sánchez, A. Niño-Pariente, E. Gallon, S. Pluchino, M.J. Vicent (CIPF, Spain).
  • P60. Poly(amidoamine)/protein conjugates Diana R. Garcia, Nathalie Lavignac(University of Kent, UK)
  • P61. Novel strategies for the physical pegylation of peptides Elena Ambrosio, Michela Barattin, Sara Bersani, Anna-Karin Lundback, Saif Shubber, Shahid Uddin, Chris van der Walle, Paolo Caliceti, Stefano Salmaso (Univ. Padova, Italy)
  • P62. High throughput synthesis of polymer biodegradable nanoparticles using microchannel emulsification: encapsulation of drugs and inorganic nanoparticles Jesus Santamaría, Victor Sebastian, Manuel Arruebo, Ane Larrea, Isabel Ortiz de Solorzano, Laura Uson.(Institute of Nanoscience of Aragon (INA), Spain)
  • P63. Surface modification of up-conversion nanoparticles with cucurbit[7]uril for photodynamic therapy Laura Francés-Soriano, María González-Béjar, Julia Pérez-Prieto (ICMol, Univ Valencia, Spain)
  • P64. Ex-vivo human haematocompatibility assessment of silk and silica nanoparticles. Manfred F. Maitz, Claudia Sperling, Thidarat Wongpinyochit, Manuela Herklotz, Carsten Werner, F. Philipp Seib(University of Strathclyde, UK)
  • P65. Folate density effect on cell internalization pathway of targeted gold nanoparticles Chiara Brazzale, Paul Moody, Paolo Caliceti, Arwyn T. Jones, Stefano Salmaso(University of Padova, Italy)
  • P66. pH-degradable cationic nanohydrogel particles for advanced siRNA delivery Nadine Leber, Leonard Kaps, Lutz Nuhn, David Schaeffel, Kaloian Koynov, Manfred Schmidt, Detlef Schupan, Rudolf Zentel. (Johannes Gutenberg University Mainz, Germany) 

19.30 - 21.00          Poster Viewing • Refreshments will be provided 


WEDNESDAY  25TH MAY 

Chairmen: S. Svenson 

Plenary 

9.00 PL4. Matthias Urmann (Sanofi Global, Germany) • Long Lasting Peptide Therapeutics: Focus on Type 2 Diabetes 

  

Polymer Anticancer Therapeutics 

Chairmen: R. Satchi-Fainaro and F. Greco 

9.45 IL17. Maria Kavallaris (University of New South Wales, Australia) Designing Polymer Therapeutics for the Treatment of Childhood Cancer 

10.15 IL18. Ayelet David (Ben-Gurion University of the Negev, Israel) Inhibition of primary and metastatic tumors in mice by E-selectin-targeted polymer-drug conjugates 

10.45-11.00 O13. Overcoming drug resistance during cancer treatment using polymer nanotherapeutics Tomáš Etrych, Alena Braunová, Petr Chytil, Milada Šírová, Anne-Kathrin Heinrich, Thomas Müller, Karsten Mäder (Institute of Macromolecular Chemistry AS CR, Czech Republic) 

11.00-11.30    Coffee/Tea • Poster Removal 

Products in Clinical Development/Clinical Use II 

Chairmen: L. Mayer and R. Gaspar 

11.30 IL19. Scott Eliasof (Cerulean Pharma Inc., USA) Clinical Experience Combining CRLX101, an Investigational Nanoparticle-Drug Conjugate, With Other Agents 

12.00 IL20. Jennifer Riggs-Sauthier (Nektar Therapeutics, USA) Successfully enabling both small molecule and biologics drugs using PEGylation technology 

12.30 IL21. Tacey Viegas (Serina Therapeutics, USA) SER-214 (polyoxazoline-rotigotine conjugate) in the treatment of Parkinson's disease 

13.00-13.15    Concluding Remarks • Meeting Closes 

Poster Only Presentations (Throughout the Conference) 

  • P67. Structural Versatile Polypeptides as excellent platforms in Polymer Therapeutics. Daniel Morelló, Luz Tortajada, Mª Dolores Iborra, Vicent J. Nebot, María J. Vicent (Polypeptide Therapeutic Solutions SL, Spain)
  • P68. Peptide-based molecular gels: mimicking protein structure and function Marta Tena-Solsona, Nishant Singh, Beatriu Escuder (Univ. Jaume I, Spain)
  • P69. Hydrid inorganic-organic corona-crosslinked polymeric micelles by sol-gel chemistry coupled to spray-drying technology as nano-drug delivery systems with controlled release performance Alejandro Sosnik, Julia Talal (Technion-Israel Institute of Technology, Israel)
  • P70. Development of nanocapsules with tunable properties for controlled release of hydrophobic cytotoxic drugs. Cristina Cuscó, Vanessa Soto-Cerrato , Ricardo Pérez-Tomás , Jordi Garcia, Ernesto Nicolás, Josep Rocas(Ecopol Tech S.L., Spain)
  • P71. Targeted gold nanoparticles as sensitizers for ultrasound-activated cancer therapy. Alessio Malfanti, Chiara Brazzale, Loredana Serpe, Roberto Canaparo, Luisa Racca, Giovanni Durando, Paolo Caliceti, Stefano Salmaso (Univ. Padova, Italy)
  • P72. Polypept(o)ides in miniemulsion technique: From long acting release systems for local application to long circulating systems for systemic delivery K. Schmidt, A. Birke, T. Fritz, M. Barz (Johannes Gutenberg University Mainz, Germany)
  • P73. Ester-Based Core-Multishell Nanocarriers for the Encapsulation of Hydrophobic Drugs Michael Unbehauen, Karolina Walker, Stefan Hönzke, Sarah Hedtrich, Rainer Haag (Freie Universität Berlin, Germany)
  • P74. Synthetic bone grafts loaded with bioactive compounds for regenerative medicine processed using solvent-free approaches Carlos A. García-González, Luis Díaz-Gómez, Leticia Goimil, Angel Concheiro, Carmen Alvarez-Lorenzo( Univ. Santiago de Compostela, Spain)
  • P75. Pulsatile drug release from electrospun poly(ethylene oxide)–sodium algenate nanofibres Abdessamad Kaassis, Nicholas P. Chatterton, Deng-Guang Yu, Gareth Williams(University College London, UK)
  • P76. Nanoemulsions from lipophilic, pH-sensitive doxorubicin prodrug impairs tumor growth and prevents distant lung metastasis in a breast cancer mice model. Gregor Nagel, Ana Lygia dos Santos Câmara, Harald R. Krüger, Camila Cardador, Luis Alexandre Muehlmann, Ricardo Bentes Azevedo, Marcelo Calderon, João Paulo Figueiró Longo (Freie Universität Berlin, Germany)
  • P77. Cutaneous delivery of polypeptide drug conjugates for topical treatment of specific skin disorders. Marwa Sallam, Daniel Morelló, Luz Tortajada, Virginia Melis, Irene Dolz, Vicent J. Nebot, María J. Vicent (Alexandria Univ., Egypt)
  • P78. Biological actions of Glycodendrimers in Alzheimer´s Disease. Dietmar Appelhans, Oxana Klementieva, Ester Aso, Josep Cladera, Isidro Ferrer, Brigitte Voit (Leibniz-Institut für Polymerforschung Dresden, Germany)
  • P79. Dendritic Glycopolymers as Efficient Drug Delivery Systems for Retarded Release of Bortezomib from Calcium Phosphate Cement.Bettina Mamitzsch, Christin Striegler, Matthias Schumacher, Michael Gelinsky, Martin Müller, Anja Seckinger, Brigitte Voit, Dietmar Appelhans (Leibniz-Institut für Polymerforschung Dresden, Germany)

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